TRF 350™ 30 capsules

Designs For Health

TRF 150™ and TRF 350™ provide nutritional support for healthy joint function, repair, and relief of occasional inflammation. These products feature Cyplexinol™ PRO, a bone derived protein/collagen complex containing Bone Morphogenetic Proteins (BMPs) and key growth factors naturally contained in bone. This ingredient helps to support the pathways involved in normal bone remodeling, and the proper repair and regeneration of cartilage, thereby supporting good bone health and joint integrity.

To support the activation of bone and cartilage formation

What is TRF 350™? 
TRF 350™ (Tissue Regeneration Factor) features 350 mg of Cyplexinol® PRO, a bone-derived protein/collagen complex containing Body/Bone Morphogenetic Proteins (BMPs) and key growth factors naturally contained in bone, such as Transforming Growth Factor Beta (TGF-β), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), and Basic Fibroblast Growth Factor (bFGF).

Applications of TRF 350™

Clinical effects of the results of supplemental BMPs are validated with multiple studies.  TRF 350™ is effective in helping to maintain bone strength and joint homeostasis, as well as the pathways which cause cartilage degradation because it features thoroughly researched Cyplexinol® PRO. The proteins (found in bone and bovine milk) contained in TRF 350™ have been shown to activate the bone and cartilage-forming process. TRF 350™ exerts its effect on bone via increasing bone formation and reducing bone resorption. This allows TRF 350™ to address the processes which lead to cartilage degradation, as well as the ensuing pain and inflammation caused by arthritis and other degenerative joint conditions.  

TRF 350™ is a higher dose than our standard TRF 150™ and should be considered for advanced stages of osteoporosis and for more serious bone and cartilage support.

TRF 350™ may be paired with OsteoForce™ (for bones) or ArthroSoothe™ (for joints).

Cyplexinol® PRO studies conclude:

  • Cyplexinol® PRO  is a bone anabolic agent  (tissue regenerating)
  • Bone volume of rats increased by 78% given Cyplexinol® PRO 
  • Promotes bone formation  and reduces bone resorption
  • Improves bone mineral density even in ovariectomized rats
  • Improves bone mass caused by estrogen decline
  • Improves trabecular bone architecture,  trabecular thickness,  and trabecular connectivity
  • Important morphogens with pleiotropic functions

Mechanisms of action:

  • Bone and Cartilage: Osteoinductive effect (stimulating new bone formation)
    Body/Bone Morphogenetic Proteins stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone) and chondrocytes (produce cartilage).
  • Arthritis (rheumatoid and osteo):   Anti-inflammatory effect
    Body/Bone Morphogenetic Proteins have an antagonistic effect towards key pro-inflammatory cytokines (such as IL-1 and IL-6) and transcription factors all which are responsible for inflammation. BMPs have been studied for both rheumatoid and osteoarthritis (these patients are low in BMPs).

TRF 350’s Cyplexinol® PRO is also involved in the maintenance and repair of articular cartilage, which covers the surface of a joint where the ends of bones meet. When this cartilage becomes damaged, the bones will grind against each other instead of having a smooth, fluid movement. Since there is no direct blood supply to cartilage, damage to these areas from injuries, misuse, or overuse leads to pain and inflammation with potentially extended recovery time.

In summary, this product is ideal for healing broken bones, osteoporosis, cartilage repair, arthritis and other degenerative joint conditions.

Serving Size:
1 capsule

Recommended Use:
As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.


Store in a cool, dry place. Keep out of reach of children.

Does not contain gluten.

** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.